Wong, Yvette, PhD

Information

Name

Wong, Yvette, PhD

Title

Assistant Professor

Email

yvette.wong@northwestern.edu

Department

Neurology

Office

Searle 7th floor Chicago

Website

https://sites.northwestern.edu/wonglab/

Areas of Research

Cell Biology, Imaging & Microscopy, Molecular Neuroscience, Neurobiology of Disease

Recent Publications on PubMed

https://pubmed.ncbi.nlm.nih.gov/?term=yvette+wong&sort=date

Current Research

Current Research

Our lab’s goal is to investigate organelle dynamics such as mitochondria and lysosomes to elucidate new pathways in cellular and neuronal biology, and diseases including neurodegeneration. Mitochondria and lysosomes are key organelles for cellular function, and their misregulation has been linked to multiple diseases. Moreover, organelles are highly dynamic and investigating their regulation in real-time is crucial for understanding cellular and neuronal homeostasis.
We are interested in: 1) Regulation and functions of inter-organelle contacts such as mitochondria-lysosome contact sites which mediate organelle crosstalk; 2) Mechanistic roles of organelle dynamics in neurodegenerative diseases such as Parkinson’s, Charcot-Marie-Tooth, Alzheimer’s, mitochondrial disorders and lysosomal diseases; and 3) Identifying new organelle dynamics using advanced imaging to discover novel pathways in cell biology and neuroscience. We use advanced live-cell microscopy in human cell lines, neurons, and various disease models to address these important questions.

Selected Publications

Selected Publications

— 1. Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis.
Nature. 2018 Feb 15;554(7692):382-386. PMID: 29364868
Wong YC, Ysselstein D, Krainc D.
— 2. Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2.
Dev Cell. 2019 Aug 5;50(3):339-354.e4. PMID: 31231042
Wong YC*, Peng W*, Krainc D.
— 3. Regulation and Function of Mitochondria-Lysosome Membrane Contact Sites in Cellular Homeostasis.
Trends Cell Biol. 2019 Jun;29(6):500-513. PMID: 3089842
Wong YC, Kim S, Peng W, Krainc D.
— 4. Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1.
PNAS. 2020 Aug 11;117(32):19266-19275. PMID: 32703809
Peng W, Wong YC, Krainc D.
— 5. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease.
Science. 2017 Sep 22;357(6357):1255-1261. PMID: 28882997
Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D.
— 6. α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.
Nature Medicine. 2017 Feb 7;23(2):1-13. PMID: 28170377
Wong YC, Krainc D.