Wang, Lei, PhD



Wang, Lei, PhD


Associate Professor


Office Phone


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Psychiatry and Behavioral Sciences and Radiology


710 N Lake Shore Drive, Abbott Hall 1322


Areas of Research

Computational, Neurobiology of Disease

Training Grants

Mechanisms of Aging and Demential Training Program (M.A.D), Training Program in the Neuroscience of Human Cognition

NU Scholar Profile

Recent Publications on PubMed

Current Research

Current Research

Our lab’s research is focused on the development of multidimensional and multimodal neuroimaging biomarkers using the tools of computational anatomy. Working with collaborators from engineering, mathematics, psychology and clinical specialties, we focus on the following major areas: 1. Mapping of Brain Structures using MRI: We develop automated pipelines to delineate brain structures based on simultaneous mappings of multiple structures from multiple atlases. This includes deep brain structures (such as the hippocampus, amygdala, thalamus, and basal ganglia) and cortical structures. 2. Complex Neuroimaging Biomarkers: We develop modeling and statistical approaches for the analysis of these maps. We develop frameworks for joint, integrated analyses of multidimensional, multimodal information based on the structural mapping of the brain. 3. Clinical Applications: We are interested in developing neuroimaging markers to characterize neuropsychiatric disorders, disease progression and prediction, and monitoring of treatment. 4. Neuroinformatics: Data sharing and data mediation. 5. Preclinical Applications: Neuroimaging of Animal Models.

Selected Publications

Selected Publications

Heritability of Multivariate Gray Matter Measures in Schizophrenia. Turner J. A., Calhoun V. D., Michael A., van Erp T. G. M., Ehrlich S., Segall J. M., Gollub R. L., Csernansky J., Potkin S. G., Ho B. C., Bustillo J., Schulz S. C., Wang L., FBIRN, Twin Research and Human Genetics 2012 Jun; 15(3):324-335
Comparison of four shape features for detecting hippocampal shape changes in early Alzheimer’s. Beg MF, Raamana PR, Barbieri S, Wang L, Statistical Methods in Medical Research 2012
Huang, L., Wang, X., Baliki, M. N., Wang, L. (*), Apkarian, A. V. (*), and Parrish, T. B. (*), 2012, Reproducibility of Structural, Resting-State BOLD and DTI Data between Identical Scanners: PLoS One, v. 7, p. e47684. (* equal contributions)
Reiter, K., Alpert, K. I., Cobia, D. J., Kwasny, M. J., Morris, J. C., Csernansky, J. C., and Wang, L., 2012, Cognitively normal individuals with AD parents may be at risk for developing aging-related cortical thinning patterns characteristic of AD: Neuroimage, v. 61, p. 525-32.
Cerebrospinal Fluid Proteins Predict Longitudinal Hippocampal Degeneration in Early-stage Dementia of the Alzheimer Type. Wang L, Fagan AM, Shah AR, Beg MF, Csernansky JG, Morris JC, Holtzman DM, Alzheimer disease and associated disorders 2011