Kozorovitskiy, Yevgenia, PhD



Kozorovitskiy, Yevgenia, PhD


Assistant Professor



Office Phone





Pancoe 2-403



Areas of Research

Circuits and Behavior, Development, Electrophysiology, Imaging & Microscopy, Molecular Neuroscience, Motor Control, Neurobiology of Disease, Neuroendocrinology

Training Grants

Mechanisms of Aging and Demential Training Program (M.A.D), Neurobiology of Information Storage Training Program (NISTP), General Motor Control Mechanisms and Disease Training Program

NU Scholar Profile


Recent Publications on PubMed


Current Research

Current Research

Synaptic and Circuit Development in the Basal Ganglia and Beyond
What are the fundamental rules governing the design of neural circuits during early life? How are these rules updated by experience and broken in disease? We investigate these questions in the basal ganglia, a phylogenetially ancient region of the brain essential for complex, goal directed motor actions and reward-based behavior. One of our primary current interests is the influence of neurotransmitters, such as glutamate, GABA and dopamine, on synaptic development and neural circuit integration in the mouse basal ganglia. To address these questions, we rely on 2-photon imaging and neurotransmitter photorelease, whole-cell electrophysiology, opto- and pharmacogenetics, neuroanatomy and behavior.

Selected Publications

Selected Publications

Kumar, M, Kishore, S, Nasenbeny, J, McLean, D, Kozorovitskiy, Y. Integrated one- and two-photon scanned oblique plane illumination (SOPi) microscopy for rapid volumetric imaging. Optics Express, 26 (10), 13027-13041. Editor's Choice.
Xiao, L, Priest, MF, Kozorovitskiy, Y. Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons. (2018). eLife, 7.
Banala*, S, Arvin*, MC, Bannon, NM, Jin, XT, Macklin, JJ, Wang, Y, Peng, C, Zhao, G, Marshall, JJ, Gee, K, Wokosin, D, Kim, VJ, McIntosh, JM, Contractor, A, Lester, HA, Kozorovitskiy Y, Drenan, RM#, Lavis, LD#. Development of photoactivatable drugs enables nicotinic optopharmacology (2018). Nature Methods, 15 (5), 347.
Urban, B, Xiao, L, Chen, S, Yang, H, Dong, B, Kozorovitskiy, Y, Zhang, HF. In Vivo Superresolution Imaging of Neuronal Structure in the Mouse Brain (2018). IEEE Transactions on Biomedical Engineering, 65 (1), 232-238. Editor's Choice, Cover.
Urban, B, Xiao, L, Chen, S, Dong, B, Kozorovitskiy, Y#, Zhang, H#. (2018). Imaging neuronal structure dynamics using two-photon super-resolution patterned excitation reconstruction (SuPER) microscopy. Journal of Biophotonics, 11 (3).
Xiao, L, Priest, MF, Nasenbeny, J, Lu, T, Kozorovitskiy, Y (2017). Biased oxytocinergic modulation of midbrain dopamine systems. Neuron, 95(2): 368-384.
Peixoto, R., Wang, W, Croney, D, Kozorovitskiy, Y, Sabatini, B (2016). Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B-/- mice. Nature Neuroscience, 19(5): 716-24.
Kozorovitskiy, Y, Peixoto, R, Wang, W, Saunders, A, Sabatini, B (2015). Neuromodulation of excitatory synaptogenesis in striatal development. eLife, 4. pii: e10111.
Tang, J, Szikra, T, Kozorovitskiy, Y, Teixiera, M, Sabatini, B, Roska, B, Cepko C (2013). A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell, 154(4): 928-39.
Kwon, H, Kozorovitskiy, Y, Oh, W, Peixoto, R, Akhtar, N, Saulnier, J, Gu, C, Sabatini, B (2012). Cortical synaptogenesis and excitatory synapse number are determined via a Neuroligin-1-dependent intercellular competition. Nature Neuroscience, 15(12):1667-74.
Kozorovitskiy, Y, Saunders, A, Johnson, C, Lowell, B, Sabatini, B (2012). Recurrent network activity drives striatal synaptogenesis. Nature, 485(7400): 646-50.