Zhu, Yongling, PhD

Selected Publications

Selected Publications

An Amacrine Cell Circuit for Signaling Steady Illumination in the Retina
Jacoby Jason, Zhu Yongling, DeVries Steven H., Schwartz Gregory W..
Cell Reports. 2015 Apr 10;doi:http://dx.doi.org/10.1016/j.celrep.2015.11.062.
PMID: 26711334 PMCID: 26711334 ISSN: 2211-1247
Genetically targeted binary labeling of retinal neurons
Zhu Yongling, Xu Jian, Hauswirth William W., DeVries Steven H..
Journal of Neuroscience. 2014 Jan;34(23):17.doi:http://dx.doi.org/10.1523/JNEUROSCI.2960-13.2014.
PMID: 24899708 PMCID: 24899708 ISSN: 0270-6474
Organizational motifs for ground squirrel cone bipolar cells
Light Adam C., Zhu Yongling, Shi Jun, Saszik Shannon, Lindstrom Sarah, Davidson Laura, Li Xiaoyu, Chiodo Vince A., Hauswirth William W., Li Wei, Devries Steven H..
Journal of Comparative Neurology. 2012 Sep;520(13):24.doi:http://dx.doi.org/10.1002/cne.23068.
PMID: 22778006 PMCID: 22778006 ISSN: 0021-9967
Two Pathways of Synaptic Vesicle Retrieval Revealed by Single-Vesicle Imaging
Zhu Yongling, Xu Jian, Heinemann Stephen F..
Neuron. 2009 Feb 12;61(3):15.doi:http://dx.doi.org/10.1016/j.neuron.2008.12.024.
PMID: 19217377 PMCID: 19217377 ISSN: 0896-6273
Synaptic vesicle exocytosis-endocytosis at central synapses
Zhu Yongling, Xu Jian, Heinemann Stephen F..
Communicative and Integrative Biology. 2009 Jan;2(5):2.doi:http://dx.doi.org/10.4161/cib.2.5.8896.
ISSN: 1942-0889
Probing synaptic vesicle fusion by altering mechanical properties of the neuronal surface membrane
Zhu Yongling, Stevens Charles F..
Proceedings of the National Academy of Sciences of the United States of America. 2008 Nov 18;105(46):5.doi:http://dx.doi.org/10.1073/pnas.0809714105.
PMID: 19004790 PMCID: 19004790 ISSN: 0027-8424
Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters
Hires Samuel Andrew, Zhu Yongling, Tsien Roger Y..
Proceedings of the National Academy of Sciences of the United States of America. 2008 Mar 18;105(11):6.doi:http://dx.doi.org/10.1073/pnas.0712008105.
PMID: 18332427 PMCID: 18332427 ISSN: 0027-8424

Information

Name

Zhu, Yongling, PhD

Title

Assistant Professor

Email

yongling-zhu@northwestern.edu

Office Phone

312-503-2141

Department

Departments of Ophthalmology and Physiology, Feinberg School of Medicine

Office

Tarry 5-723

Areas of Research

Circuits and Behavior, Computational, Electrophysiology, Imaging & Microscopy, Molecular Neuroscience, Sensory Systems

NU Scholar Profile

http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=24979

Recent Publications on PubMed

http://www.ncbi.nlm.nih.gov/sites/myncbi/yongling.zhu.1/bibliography/50104474/public/?sort=date&direction=ascending.

Current Research

Current Research

The goal of my research is to understand the visual processing in the retina. Specifically, I am interested in how visual information is abstracted by the complex inhibitory and excitatory interactions centered around ganglion cell dendrites. The retina is an excellent model system for studying neural circuits, but the complex wiring among bipolar, amacrine, and ganglion cells within the dense, tortuous IPL impedes our understanding of how visual information is processed. A major focus of our group is to develop new technologies in the mouse model system to access to highly specific sets of neurons and circuits for structural and functional studies with an increased spatial and temporal resolution. We pair powerful mouse genetic strategies with an array of advanced viral vector technologies to delineate and label cell types in the retina, followed by electrophysiology, functional imaging and optogenetics to dissect and analyze specific circuits. We use both discovery based and hypothesis driven approaches to better understand how specific subsets of neurons integrate into larger circuits that compute different neural representations of the visual world.