Gelfand, Vladimir, PhD

Information

Name

Gelfand, Vladimir, PhD

Title

Professor

Email

vgelfand@northwestern.edu

Office Phone

312-503-0530

Department

Cellular and Molecular Biology

Office

Ward 8-140 Chicago

Website

http://www.gelfandlab.northwestern.edu/

Areas of Research

Cell Biology, Molecular Neuroscience

NU Scholar Profile

http://www.scholars.northwestern.edu/expert.asp?u_id=773

Recent Publications on PubMed

http://www.ncbi.nlm.nih.gov/pubmed?term=Gelfand%2C%20Vladimir%5BFull%20Author%20Name%5D&cmd=DetailsSearch

Current Research

Current Research

Neurons are polarized cells containing elaborated processes called axons and dendrites. Intracellular transport of organelles, RNA, and protein complexes from the cell body into axons and dendrites is essential for neuronal viability. Transport of cargoes in the cells is performed by motor proteins, kinesins and dyneins that move along microtubules, and myosins that move along actin filaments. Defects in the transport processes are associated with a number of neurological diseases, including Alzheimer disease and mental retardation syndromes.

The main interest in the Gelfand laboratory is to elucidate the mechanisms and regulation of intracellular transport in neurons and other cells. To investigate these questions, we combine high-resolution digital imaging with a number of molecular biology and biochemistry techniques. Biological models of transport that are studied in our laboratory include transport of fragile X mental retardation protein (FMRP) and its associated mRNAs as well as transport of membrane organelles in neurons and non-neuronal cells. More detailed description of our research and specific questions we are truing to address can be found on the lab web page at http://www.gelfandlab.northwestern.edu and in our publications (see below).