Daniel Procissi

Current Research

Current Research

My research focuses on the use of advanced preclinical imaging techniques such as MRI, PET and CT to explore brain anatomy, function and metabolism in different types of animal models.
The ability to extract information from MR, PET and CT images which reflects biological processes underlying disease is an essential tool to develop novel biomarker assays for therapeutic assessment and also provides a complementary way to corroborate findings obtained using other techniques (histology, behavioral, electrophysiology etc etc).
Importantly the imaging methods used in the laboratory are non-invasive and can be performed longitudinally on the same subjects. In addition the scanners used for these measurements mimic in every aspect the human/clinical ones, adding a very distinctive translational value to all the studies conducted.

General areas of research being pursued in the laboratory can be organized as: 1) cognitive neuroimaging (fMRI, Manganese MRI, PET-FDG) in different animal models; 2) high resolution 3D morphometric and connectivity assessment of brain structures in neurodegenerative and genetic disease models (MRI and PET); 3) multi-parametric imaging assays of brain disease and/or injury (cancer ,TBI, ischemic injury, neurodegenerative disease).

The research conducted in the laboratory is strongly multidisciplinar requiring technical and computational skills as well as theoretical knowledge of the principles and ideas behind the imaging technologies, but also a deep understanding of neurobiology and neuroanatomy.

Selected Publications

Selected Publications

1) Intrinsic connectivity networks in the awake rabbit. Matthew P Schroeder, Craig Weiss, Daniel Procissi, Lei Wang, John F. Disterhoft Neuroimage (accepted) 2015
2) BOLD fMRI and AIM-MRI in awake rabbits during somatosensory stimulation. Matthew P Schroeder, Craig Weis, Daniel Procissi, Lei Wang, John F. Disterhoft, Neuroimage (accepted) 2015
3) Pretrial functional connectivity differentiates behavioral outcomes during trace eyeblink conditioning in the rabbit. Matthew P Schroeder, Craig Weis, Daniel Procissi, Lei Wang, John F. Disterhoft Neuroimage (in review) 2015
4) Functional MRI in the Awake Rat Pei-Ching Chang, Daniel Procissi, Qiyuan Bao, Maria Virginia Centeno, Alex Baria, A. Vania Apkarian
Human Brain Mapping (in review) 2015

5) Aberrant resting-state functional connectivity in a genetic rat model of depression.
Williams KA, Mehta NS, Redei EE, Wang L, Procissi D.
Psychiatry Res. 2014 Apr 30;222(1-2):111-3. PMID: 24613017

6) Role of nucleus accumbens in neuropathic pain: linked multi-scale evidence in the rat transitioning to neuropathic pain.
Chang PC, Pollema-Mays SL, Centeno MV, Procissi D, Contini M, Baria AT, Martina M, Apkarian AV.
Pain. 2014 Jun;155(6):1128-39. PMID: 24607959

7) CNS demyelination in fibrodysplasia ossificans progressiva.
Kan L, Kitterman JA, Procissi D, Chakkalakal S, Peng CY, McGuire TL, Goldsby RE, Pignolo RJ, Shore, EM, Kaplan FS, Kessler JA.
J Neurol. 2012 Dec;259(12):2644-55.

8) Quantitative pharmacologic MRI in mice.
Perles-Barbacaru TA, Procissi D, Demyanenko AV, Jacobs RE
NMR Biomed. 2012 Apr;25(4):498-505

9) Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice.
Perles-Barbacaru TA, Procissi D, Demyanenko AV, Hall FS, Uhl GR, Jacobs RE.
Neuroimage. 2011 Mar 15;55(2):622-8. PMCID: PMC3035982

Information

Name

Daniel Procissi

Title

Research Associate Professor

Email

d-procissi@northwestern.edu

Office Phone

312-503-2247

Department

Radiology & Biomedical Engineering

Office

Olson Pavilion 0-271

Website

http://cti.northwestern.edu/samri/

Areas of Research

Brain Imaging (FMRI etc.), Computational, Imaging & Microscopy, Mechanisms of Drug Action, Molecular Neuroscience, Neurobiology of Disease

NU Scholar Profile

http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=18660

Recent Publications on PubMed

http://www.ncbi.nlm.nih.gov/pubmed/?term=Procissi