Bevan, Mark D., PhD

Information

Name

Bevan, Mark D., PhD

Title

Professor

Email

m-bevan@northwestern.edu

Office Phone

312-503-4828/ 312-909-0175

Office Fax

312-503-5101

Department

Physiology

Office

Tarry-754/756/757/758, Lurie 8-204 Chicago

Website

http://bugs.mimnet.northwestern.edu/bevanlab

Areas of Research

Motor Control, Neurobiology of Disease

Training Grants

General Motor Control Mechanisms and Disease Training Program

NU Scholar Profile

https://northwestern.pure.elsevier.com/en/persons/5c24316d-acf5-449c-a7c6-b5bee2416eb7

Recent Publications on PubMed

http://www.ncbi.nlm.nih.gov/pubmed?term=Bevan+MD&cmd=DetailsSearch

Current Research

Current Research

Our work is focused on the basal ganglia – a group of subcortical brain nuclei critical for voluntary movement, associative learning and motivation and the primary site of dysfunction in psychomotor disorders like Parkinson’s disease, Huntington’s disease, OCD and addiction. We are particularly interested in the mechanisms underlying:

the activity patterns of the subthalamic nucleus-globus pallidus network in health and in Parkinson’s disease and Huntington’s disease;
the therapeutic effectiveness of high-frequency electrical stimulation of the subthalamic nucleus in Parkinson’s disease;
the selective vulnerability of substantia nigra dopamine neurons in Parkinson’s disease.

Our research is funded by NIH-NINDS, the Parkinson’s Disease Foundation and CHDI. We utilize multiple approaches including electrophysiology, 2-photon imaging and glutamate uncaging, anatomical and molecular profiling and optogenetics.

Selected Publications

Selected Publications

Atherton JF, Wokosin DL, Ramanathan S, Bevan MD (2008) Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. J Physiol 586: 5679-5700.

Baufreton J, Kirkham E, Atherton JF, Menard A, Magill PJ, Bolam JP, Bevan MD (2009) Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus. J Neurophysiol 102: 532-545.

Blythe SN, Wokosin D, Atherton JF, Bevan MD (2009) Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons. J Neurosci 29: 15531-41.

Atherton JF, Kitano K, Baufreton J, Fan K, Wokosin D, Tkatch T, Shigemoto R, Surmeier DJ, Bevan MD (2010) Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus. J Neurosci 30: 16025-16040.