Parisiadou, Loukia, PhD

Information

Name

Parisiadou, Loukia, PhD

Title

Assistant Professor

Email

loukia.parisiadou@northwestern.edu

Office Phone

312 503 2652

Department

Pharmacology

Office

Lurie 8-127

Website

https://parisiadoulab.com/

Areas of Research

Cell Biology, Molecular Neuroscience, Motor Control, Neurobiology of Disease, Signal Transduction

Training Grants

Mechanisms of Aging and Demential Training Program (M.A.D)

Recent Publications on PubMed

https://www.ncbi.nlm.nih.gov/pubmed/?term=Loukia+Parisiadou

Current Research

Current Research

Our research focuses on the molecular basis of Parkinson’s disease (PD). To achieve this, we study the cellular and molecular events by which mutations in genes linked to PD contribute to disease pathology. PD has been classically considered a sporadic disease, however, it is now recognized to have a substantial genetic component. Interestingly, the same genes involved in the autosomal-dominantly inherited forms of PD such as SNCA (α-synuclein), and LRRK2 can act as risk factors in sporadic PD, as well. Given the relevance of LRRK2 and α-synuclein with the sporadic forms of PD, our long-term research goal by interrogating a-synuclein and mainly LRRK2-dependent alterations at the cellular, network and behavioral levels is to understand the pathophysiology of PD. The gained knowledge will provide useful insights towards the development of mechanism-based therapeutic opportunities for a disease that is currently addressed symptomatically.

Selected Publications

Selected Publications

1. Parisiadou L#, Yu J, Sgobio C, Xie C, Liu G, Sun L, Gu XL, Lin X, Crowley NA, Lovinger DM, Cai H#. LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nature Neuroscience. 2014, 17(3):367-76 (# co-corresponding authors)
4. Lin X*, Parisiadou L*, Sgobio C, Liu GX, Yu J, Sun L, Shim H, Gu XL, Luo J, Long CX, Ding J, Mateo Y, Sullivan P, Wu LG, Goldstein D, Lovinger D, and Huaibin Cai (*equal contribution). Conditional Expression of Parkinson disease-related Mutant A53T α-synuclein in the Midbrain Dopaminergic Neurons causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1. Journal of Neuroscience. 2012, 32(27):9248-64 (*equal contribution)
3. Parisiadou L, Xie C, Lin X, Gu XL, Long CX, Lobbestael E, Baekelandt V, Taymans JM, Sun L, Cai H. Phosphorylation of ERM proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. Journal of Neuroscience. 2009, 29(44):13971-80.
4. Lin X*, Parisiadou L*, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, Chen ZZ, Gallant PE, Tao-Cheng JH, Rudow G, Troncoso JC, Liu Z, Li Z, Cai H. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009, 64(6):807-27 (*equal contribution).