Miller, Lee, PhD

Current Research

Current Research

The primary goal of the research in my lab is to understand the nature of the somatosensory and motor signals within the brain that are used to control arm movements. Most of the experiments in my laboratory rely on multi-electrode arrays that are surgically implanted in the brains of monkeys. These “neural interfaces” allow us to record simultaneously from roughly 100 individual neurons in the somatosensory and motor cortices and thereby study the brain’s own control signals as the monkey makes reaching and grasping movements. We can also pass tiny electrical currents through the electrodes to manipulate the natural neural activity and study their effect on neural activity and the monkey’s behavior.

Current projects seek to understand, 1) how motor cortical activity leads to the complex patterns of muscle contractions needed to produce movement, and 2) how movement of the limb and forces exerted by the hand are “encoded” in the activity of neurons in the somatosensory cortex. We also study how these relations are affected by behavioral context: the magnitude and dynamics of exerted forces, the varied requirements for sensory discrimination, and the quality of the visual feedback that is provided to the monkey to guide its movements.

Along with this basic research, we can use these neural interfaces to bypass the peripheral nervous system, in order to connect the monkey’s brain directly to the outside world. We are developing neural interfaces that ultimately will use signals recorded from the brain to allow patients who have lost a limb to operate a prosthetic limb. The interface may also be used to bypass a patient’s injured spinal cord in order to restore voluntary control of their paralyzed muscles. Conversely, electrical stimulation of the brain will restore the sense of touch and limb movement to patients with limb amputation or spinal cord injury. This highly interdisciplinary work is enabled by numerous collaborations at Northwestern University and other institutions.



Miller, Lee, PhD




Office Phone


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Ward 5-313


Areas of Research

Motor Control, Movement & Rehabilitation

NU Scholar Profile

Recent Publications on PubMed