Gottfried, Jay A., MD, PhD



Gottfried, Jay A., MD, PhD




Office Phone

312-503-3185; 312-503-3085

Office Fax





Ward 13-270 Chicago


Areas of Research

Brain Imaging (FMRI etc.), Cognition&Language, Learning & Memory, Sensory Systems

Training Grants

Mechanisms of Aging and Demential Training Program (M.A.D), Neurobiology of Information Storage Training Program (NISTP)

NU Scholar Profile

Recent Publications on PubMed

Current Research

Current Research

Understanding the links between brain activity and sensory perception is a central question that has long inspired neuroscience research. While much of this work has focused on the neural processing of visual objects and visual object categories (e.g., faces, houses, gnomes, supervillains), little is known about the neural processing of odor objects, that is, the quality or character of a smell arising from an odorous object (e.g., minty, lemony, wet-dog, baked bread). Where, and in what form, is perceptual information about odor quality coded in the olfactory brain? What is the neural signature corresponding to the perceived fragrance of chocolate, or of cheese? How do learning and experience modulate perceptual codes of odor objects?

The primary research objective in our lab is to clarify the functional architecture of odor quality coding in the human brain. Our laboratory combines olfactory functional magnetic resonance imaging (fMRI) with different psychophysics paradigms, physiological recordings, and multivariate (pattern-based) statistical approaches to clarify the links between brain function, perception, learning, and behavior. More recently we have begun using intracranial EEG (iEEG) techniques in patients with medically resistant epilepsy to elucidate the rapid (millisecond) spatiotemporal dynamics of odor processing in the human olfactory (piriform) cortex, amygdala, hippocampus, and orbitofrontal cortex. Insights gained from this work will represent an important step forward in clarifying the neurobiology of the human olfactory system.