Bozza, Thomas, PhD

Information

Name

Bozza, Thomas, PhD

Title

Associate Professor

Email

bozza@northwestern.edu

Office Phone

847-467-2870

Office Fax

847-491-5211

Department

Neurobiology

Office

Pancoe 2-119 Evanston

Website

http://groups.nbp.northwestern.edu/bozza/

Areas of Research

Circuits and Behavior, Electrophysiology, Imaging & Microscopy, Molecular Neuroscience, Sensory Systems

NU Scholar Profile

https://northwestern.pure.elsevier.com/en/persons/29233f14-88fa-4a98-a5e3-591058f08a95

Recent Publications on PubMed

http://www.ncbi.nlm.nih.gov/pubmed?term=Bozza%2C%20Thomas%5BFull%20Author%20Name%5D&cmd=DetailsSearch

Current Research

Current Research

The main interest of the lab is to understand how activity in neuronal circuits gives rise to stimulus perception and innate behavior in mammals. As an entry point, we are studying the mouse olfactory system. The vertebrate olfactory system is a remarkable molecular recognition device, and is arguably the most genetically tractable of the senses in any species. In addition, odors can elicit specific behavioral responses in mice.
Olfactory stimuli are detected by an array of sensory neurons in the nasal cavity, each of which expresses a single odorant receptor gene. Neurons expressing the same receptor make specific connections to discrete structures (called glomeruli) in the olfactory bulb. In this way, the odorant receptor repertoire (~1000 genes in the mouse) is mapped onto the array of glomeruli in the brain. Our laboratory uses a combination of mouse genetics, in vivo imaging, electrophysiology, optogenetics, and behavior to investigate how genetically-defined populations of sensory neurons contribute to olfactory perception.

Selected Publications

Selected Publications

Dewan, A., Pacifico, R, Zhan, R., Rinberg, D. and Bozza, T. (2013) Nonredundant coding of aversive odours in the mouse olfactory system. Nature. 497, 486–489.

Smear, M, Resulaj A, Zhang, J, Bozza, T, Rinberg D. (2013) Multiple perceptible signals from a single olfactory glomerulus. Nature Neuroscience. 16(11):1687-1691.

Zhang J, Pacifico R, Cawley D, Feinstein P, Bozza T. (2013) Ultrasensitive detection of amines by a trace amine-associated receptor. The Journal of Neuroscience. 33(7):3228-3239.

Pacifico, R., Dewan, A., Cawley, D., Guo, C., and Bozza, T. (2012). An Olfactory Subsystem that Mediates High-Sensitivity Detection of Volatile Amines. Cell Reports 2(1) 76-88 http://dx.doi.org/10.1016/j.celrep.2012.06.006

Zhang J, Huang G, Dewan A, Feinstein P, Bozza T. (2012) Uncoupling stimulus specificity and glomerular position in the mouse olfactory system. Molecular and Cellular Neuroscience 51(3-4):79-88.

Smear, M., Shusterman, R., O'Connor, R., Bozza, T., and Rinberg, D. (2011). Perception of sniff phase in mouse olfaction. Nature 479, 397-400

Bozza, T., Vassalli, A., Fuss, S., Zhang, J.-J., Weiland, B., Pacifico, R., Feinstein, P., and Mombaerts, P. (2009) Mapping of Class I and Class II Odorant Receptors to Glomerular Domains by Two Distinct Types of Olfactory Sensory Neurons in the Mouse. Neuron 61: 220–233.