George, Jr., Alfred, MD

Information

Name

George, Jr., Alfred, MD

Title

Magerstadt Professor and Chair

Email

al.george@northwestern.edu

Office Phone

312-503-4892

Department

Pharmacology

Office

Searle 8-510

Areas of Research

Electrophysiology, Mechanisms of Drug Action, Molecular Neuroscience, Neurobiology of Disease

NU Scholar Profile

https://northwestern.pure.elsevier.com/en/persons/b5df82a1-68ca-4c90-b20f-da834eb0b21b

Recent Publications on PubMed

https://fsmweb.northwestern.edu/faculty/viewpub2.cfm?xid=29140

Current Research

Current Research

Our research program is focused on the structure, function, pharmacology, and molecular genetics of ion channels. His laboratory has contributed greatly to understanding the mechanisms by which ion channel mutations cause a variety of inherited disorders of membrane excitability including congenital cardiac arrhythmia susceptibility and epilepsy. These basic and translational investigations have provided many opportunities to investigate the relationship between structure and function in ion channels and have helped establish important genotype-phenotype correlations for several human diseases and certain animal models. We were first to elucidate the functional consequences of an ion channel mutation linked to an inherited cardiac arrhythmia (Long-QT Syndrome). This discovery contributed greatly to understanding arrhythmia susceptibility in the disease and inspired use of drugs targeting persistent sodium current as a therapeutic strategy. Recently, the use of exome sequencing enabled us to discover human calmodulin mutations in congenital arrhythmia syndromes. Our studies of the molecular basis for genetic epilepsy have revealed new targets for antiepileptic drug development.

Selected Publications

Selected Publications

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice.
Mistry AM, Thompson CH, Miller AR, Vanoye CG, George AL, Kearney JA
Neurobiology of disease 2014 May; 65:1-11
PMID: 24434335

Mechanism of sodium channel NaV1.9 potentiation by G-protein signaling.
Vanoye CG, Kunic JD, Ehring GR, George AL
The Journal of general physiology 2013 Feb; 141(2):193-202
PMID: 23359282

Nontruncating SCN1A mutations associated with severe myoclonic epilepsy of infancy impair cell surface expression.
Thompson CH, Porter JC, Kahlig KM, Daniels MA, George AL
The Journal of biological chemistry 2012 Dec 7; 287(50):42001-8
PMID: 23086956