Guemez Gamboa, Alicia PhD

Information

Name

Guemez Gamboa, Alicia PhD

Title

Assistant Professor

Email

alicia.guemez@northwestern.edu

Office Phone

(312) 503-0752

Department

Physiology

Office

Ward 5-654, Chicago

Website

http://sites.northwestern.edu/guemezgamboalab

Areas of Research

Cell Biology, Circuits and Behavior, Development, Molecular Neuroscience, Neurobiology of Disease

NU Scholar Profile

http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=36264

Recent Publications on PubMed

https://www.ncbi.nlm.nih.gov/sites/myncbi/1bsvwVdWtucAd/bibliography/41058261/public/?sort=date&direction=ascending

Current Research

Current Research

To determine the molecular mechanisms that specify neuronal connectivity, our lab focuses on two interconnected areas of study:

Investigating molecular pathways that specify cellular recognition in brain wiring during development
Identification and genetic characterization of molecular mechanisms pertaining to brain connectivity defects in humans

To explore the broader roles for cell recognition molecules and their pivotal function in neural circuit development, our lab takes advantage of a battery of modern laboratory techniques. These approaches include animal and stem cell disease modeling, as well as next-generation sequencing and CRISPR/Cas9 gene editing.

Selected Publications

Selected Publications

Guemez-Gamboa A*, Nguyen LN*, Yang H*, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Cazenave-Gassiot A, Quek D, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG. (2015) Inactivating Mutations in MFSD2A, Required for Omega-3 Fatty Acid Transport in Brain, Result in a Lethal Microcephaly Syndrome. Nature Genetics. 47(7):809-13. PMID: 26005868. * equal contribution.
Guemez-Gamboa A, Coufal N, Gleeson JG. (2014) Emerging roles for the cilia in the central nervous system. Neuron. 82(3): 511-21. PMID: 24811376.
Baek ST, Copeland B, Yun EJ, Kwon SK, Guemez-Gamboa A, Kim S, Kang HC, Song S, Mathern G, Gleeson JG. An AKT3-FOXG1-Reelin Network Underlies Defective Migration in Human Focal Malformations of Cortical Development (2015). Nature Medicine. 21(12):1445-54. PMID: 26523971.
Lardelli R., Schaffer A., Eggens V., Zaki M., Grainger S., Sathe S.,VanNostrand E., Schlachetzki Z., Rosti B., Aquizu N., Scott E., Heckman L., Rosti R., Dikoglu E., Gregor A., Guemez-Gamboa A., Musaev D., Mande R., Widjaja A., Shaw T., et al., (2017) Biallelic mutations in the 3' exonuclease TOE1 cause Pontocerebellar Hypoplasia Type 7 and uncover a role in snRNA processing. Nature Genetics. In press. PMID: 28092684.